招聘簡介：

　　描述

　　在比利時(shí)布魯塞爾Iribhm由Benjamin Beck領(lǐng)導(dǎo)的“食管癌和化生特征”實(shí)驗(yàn)室（https://www.benjamin beck lab.com）有一個(gè)獲得資助的兩年博士后職位（https://iribhm.org）。我們的實(shí)驗(yàn)室有興趣通過多種技術(shù)和幾種轉(zhuǎn)基因小鼠模型來描述化生的發(fā)展及其向癌癥發(fā)展的機(jī)制。

　　項(xiàng)目大綱

　　食管柱狀化生是腺癌的主要危險(xiǎn)因素之一。我們的目的是了解食管細(xì)胞是如何經(jīng)歷一個(gè)轉(zhuǎn)分化過程來產(chǎn)生化生的，以及后者是如何發(fā)展成腺癌的。為此，我們將使用基于轉(zhuǎn)基因小鼠模型、器官培養(yǎng)、條件敲除和過度表達(dá)系統(tǒng)、facs分類細(xì)胞的表觀遺傳和轉(zhuǎn)錄測序以及crispr/cas9基因編輯的多學(xué)科方法。我們建議挑戰(zhàn)肥胖、慢性炎癥和致癌作用對柱狀化生向腸道化生和癌癥進(jìn)展的影響。

　　英文原文：

　　Description

　　A funded two-year postdoctoral position is available in the “Characterization of Esophageal Cancers and Metaplasia” lab (https://www.benjaminbecklab.com) headed by Benjamin Beck at the IRIBHM, Brussels, Belgium (https://iribhm.org). Our lab is interested in characterizing the mechanisms involved in the development of metaplasia and their progression into cancer by using a variety of techniques and several transgenic mouse models.

　　Project Outline

　　Columnar metaplasia of the esophagus constitutes one of the main risk factors for adenocarcinoma. We aim at understanding how esophageal cells undergo a process of transdifferentiation to generate metaplasia and how the latter then progress into adenocarcinoma. To this end, we will use a multidisciplinary approach based on transgenic mouse models, organoid culture, conditional knockout and overexpression systems, epigenetic and transcriptomic sequencing of FACS sorted cells as well as CRISPR/Cas9 gene editing. We propose to challenge the impact of obesity, chronic inflammation and oncogenic hits on the progression of columnar metaplasia towards intestinal metaplasia and cancer.

　　Profile

　　The applicants of any nationality must hold a PhD and/or a MD degree (for less than 7 years) and should be highly motivated. The applicants should have a strong background in cancer biology. Technical expertise in handling transgenic mouse models, organoids and/or CRISPR/Cas9 gene editing will be of advantage. Excellent communication skills are expected.

　　How to apply?

　　Interested candidates are encouraged to submit a motivation letter describing their background, a CV and two references letters to Benjamin Beck (benjamin.beck@ulb.ac.be).

　　Please visit our website for more information: https://www.benjaminbecklab.com.

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