Postdoctoral Fellow

European Molecular Biology Laboratory

Description

Postdoctoral Fellow Location: Heidelberg, Germany

Staff Category: Postdoctoral Fellow Contract Duration: 18 months Grading: Stipend Closing Date: 28 February 2021 Reference Number: HD01913

The European Molecular Biology Laboratory (EMBL) is seeking a bright postdoctoral candidate to investigate the control of cell and tissue mechanics via optogenetics in a collaborative project between Maria Leptin (EMBL- Heidelberg, Germany) and Vito Conte at the Eindhoven University of Technology (TU/Eindhoven, the Netherlands). The project to research the role of cell cortex contractility in regulating mechanics and morphology of in vitro epithelial tissues is funded by the Volkswagen Foundation for 18 months.

Your role

The successful candidate will be based at the EMBL-Heidelberg in the Leptin Lab. The first stage of the project will focus on engineering an in vitro optogenetic cellular model that can selectively regulate the mechanics of the cellular cortex and its subdomains. Mechanical features of the optogenetic cell model will subsequently be tested at the TU/Eindhoven in the Conte Lab.

The in vitro experimental methods involved in this inquiry will include: i) a wide spectrum of molecular and cell biology techniques for the (optogenetical) manipulation of both cellular genotype and phenotype (e.g. plasmid engineering transfection/transduction, selection etc..); ii) advanced microscopy (including epifluorescence, phase contrast and confocal microscopy). To create the new cellular model, the candidate will build on established experimental protocols and optogenetic constructs as well as create new ones.

You have

We are accepting applications from enthusiastic and highly talented PhDs who are interested in a dynamic, stimulating and ambitious environment to perform their research. We are looking for candidates who meet the following requirements:

  A background in molecular and cell biology. Previous experience with optogenetics, microscopy techniques or 2D/3D cell culture will be a distinct advantage, along with competencies in computer-based quantification and analysis of experimental images (Matlab, ImageJ/FiJi or similar).

  Ability to effectively communicate scientific ideas and have a capability for independent thinking.

  Ability to work independently within a dynamic team and be proficient in written and spoken English.

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