Grade 7 (£29,541-£36,298)

Postdoctoral positions in the laboratory of Prof. John Rouse at the MRC Protein Phosphorylation and Ubiquitylation Unit, The Sir James Black Centre, University of Dundee, Scotland.

Applications are invited for two postdoctoral positions in the lab of John Rouse to study the mechanisms which cells use to cope with DNA damage. In the past few years the Rouse lab has identified several important new regulators of genome stability including the FAN1 nuclease (Cell 142, 65-76), the SLX4 complex of nucleases (Molecular Cell 35, 116-127), the MMS22L-TONSL complex (Molecular Cell 40, 632-644) and DVC1 (Nat. Struct. Mol. Biol. 19, 1093-1100). Bright, enthusiastic individuals are sought to join our team to decipher the cellular roles of other new regulators of genome stability, and to investigate new modes of DNA repair in mammalian cells.

MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):

The Rouse lab is based in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the College of Life Sciences at the University of Dundee. The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation. Many world leading researchers in the field of signal transduction have trained within the MRC-PPU. The major aims of the MRC-PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation, to generate reagents and improve technologies. Another key remit of the MRC-PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research. The MRC-PPU is in a beautiful location overlooking the estuary of the River Tay and embedded within the College of Life Sciences at the University of Dundee which is one of the premier Life Sciences research Centres in the world.

The postdoctoral positions will be for 3 years on the University of Dundee grade 7 scale (£29,541-£36,298).

Candidate requirements:

• PhD with outstanding academic track record and at least one first authored publication in an internationally recognised peer-reviewed journal
• Strong background in biochemistry, molecular biology and analysis of DNA repair in eukaryotes
• Ability to work as part of a team, but able to plan and work independently
• Excellent communication skills and proficiency in English

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