英國劍橋制藥公司博士后職位

　　Job Title: Sustaining Innovation Postdoctoral Research Associate

　　Project Title: Exploiting CRISPR tiling technology to identify functionally important regions of proteins

　　Job Type: 3 Year Fixed Term Contract, Full Time

　　Location: Cambridge, UK

　　Astex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery platform to generate multiple new drug candidates that are progressing in clinical development. Successful collaborations have led to two launched oncology drugs (Kisqali® partnered with Novartis and BalversaTM partnered with Janssen). Astex continues to grow and focuses on Oncology and Neurological Disorders.

　　CURIOSITY, CREATIVITY AND INNOVATIVE SCIENCE FOR DRUG DISCOVERY

　　…UNLOCK YOUR POTENTIAL

　　The Astex Sustaining Innovation Postdoctoral research program has a track record of performing cutting-edge research and development and is a key element of our excellent scientific culture. During your SI Postdoc project you will be exposed to a multi-disciplinary pharma environment. You’ll benefit from our internal training seminars that will enhance your understanding of the drug discovery process. As part of your career development, you will have the opportunity to present your work within the company and at external meetings and you’ll be expected to publish your findings in high-impact journals.

　　As a member of the Translational Biology department, the successful candidate will establish and apply CRISPR tiling technologies to identify protein domains that are critical for cell viability and acquired resistance to signal transduction inhibitors. In order to further understand the biology of cancer pathways, the candidate will perform additional validation studies using a range of cell and molecular biology techniques.

　　Candidate Requirements

　　•A PhD in a biological science and a strong publication record

　　•Direct experience and technical expertise using CRISPR

　　•Demonstrable proficiency in a range of cell and molecular biology techniques including transient and stable genetic manipulation of cells

　　•The ability to contribute within highly multidisciplinary teams and work in a highly collaborative manner.

　　We offer excellent training and career development opportunities as well as competitive salary and benefits package.

　　Closing Date: 29th May 2020

　　To apply please send your CV and a cover letter, quoting the job reference: SI-B002 to hr.uk@astx.com

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